Thursday, February 26, 2009

About Viagra

1. Name of medicine

Viagra

2. Quantitative and qualitative

Active ingredient: sildenafil citrate

Viagra 25 mg: tablet contains sildenafil citrate at a dose equivalent to 25 mg sildenafil.

Viagra 50 mg: tablet contains sildenafil citrate at doses equivalent to 50 mg sildenafil.

Viagra 100 mg: tablet contains sildenafil citrate in a dosage of 100 mg sildenafil.

The list of inactive ingredients

Microcrystalline cellulose, calcium gidrofosfat (anhydrous), kroskarmelloza sodium, magnesium stearate, gipromelloza, titanium dioxide (E171), lactose, triatsetin, lacquer aluminum indigo carmine (E132).

3. Pharmacological properties

Sildenafil; ATC code G04V E

3.1. Pharmacodynamic properties

Viagra is a new oral medication designed to treat erectile dysfunction. A violation is restored erectile function and provides a natural response to sexual arousal.

Physiological mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. Nitric oxide activates the enzyme guanilattsiklazu, leading to increased levels of cyclic guanozinmonofosfata (tsGMF), relaxation of smooth muscles of cavernous bodies and increasing the blood flow to the penis.

Sildenafil is a potent and selective inhibitor specific tsGMF-fosfodiesterazy type 5 (FDE5), which is responsible for the collapse of the tsGMF in the corpus cavernosum. Viagra has an effect on peripheral arousal. Sildenafil has no direct relaxant effect on corpus cavernosum but also actively improving the relaxing effect of NO in this tissue. When the road Navarre / tsGMF observed in sexual initiation, inhibition FDE5 influenced sildenafil leads to increased levels of tsGMF in the corpus cavernosum. Thus, for the demonstration of a favorable pharmacological effect of Viagra requires sexual stimulation.

When receiving a single dose of Viagra in the 100 mg in healthy volunteers, the drug produced no clinically significant changes in ECG. The maximum decrease in systolic blood pressure in the prone position in the application of the drug into a dose of 100 mg was on average 8.4 mm Hg. Section A decrease in diastolic blood pressure in the prone position was 5.5 mm Hg. Art Reducing blood pressure is vazodilatiruyuschimi sildenafil effects, possibly through raising tsGMF in vascular smooth muscle.

Viagra has no effect on visual acuity and contrast perception. Some patients in 1 hours after taking the drug in a dose of 100 mg showed mild and transient violation distinguish colors (blue / green) using the Farnsworth-Munsell test 100, at 2 h after taking medication, these changes were absent. The mechanism provided for violations of oppression felt FDE6 color, which is involved in the transfer of light in the retina. In vitro studies have shown that the effect of sildenafil FDE6 10 times lower than its activity against FDE5.

In vitro studies indicate that the activity against sildenafil FDE5 10 -10 000 times larger than its activity against other isoforms fosfodiesterazy (FDE 1, 2, 3, 4 and 6). In particular, activity against FDE5 4 sildenafil 000 times larger than its activity against FDE3 - tsAMF specific fosfodiesterazy involved in the reduction of the heart.

3.1.1. For more information on clinical trials

Efficacy and safety of Viagra has been studied in 21 randomized, double-blind study platsebokontroliruemom for 6 months. Viagra used by more than 3,000 patients with erectile dysfunction of various etiologies (organic, psychogenic, mixed), aged 19 to 87 years. Effectiveness is determined by the overall assessment, the newspapers, the assembly of registration, evaluation of the International Index of Erectile Function (IIEF, a questionnaire to assess sexual function), and the survey of partners.

Effectiveness of Viagra, which is estimated by the drug’s ability to attack, and the preservation of an erection sufficient for sexual intercourse, has been demonstrated in 21 studies, and persisted over the long term (one year). If you use drugs in fixed doses, the proportion of patients reported improvement in erectile function was 62% (25 mg), 74% (50 mg) and 82% (100 mg), and to receive a placebo - 25% . In addition to improving erectile function, IIEF results showed that the treatment of Viagra also improved orgasm, satisfaction from sexual intercourse and overall satisfaction.

In all studies, the proportion of diabetic patients, improvements in the treatment of Viagra amounted to 59% of patients experienced a radical prostatektomiyu - 43% of patients with spinal cord injury - 83% (vs. 16%, 15 % and 12% of patients receiving placebo, respectively).

3.2. Pharmacokinetic properties

Intake

Viagra readily absorbed. The concentration of drug in plasma after administration in the stomach reaches its peak within 30-120 minutes (mean 60 min). The absolute bioavailability of oral, with an average of 41% (25-63%). The pharmacokinetics of the ingestion of Viagra in the range of doses (25-100 mg) is linear.

When you receive Viagra in combination with fatty food intake rate decreases; Tmax is increased by 60 minutes, and Cmax were reduced by half from 29%.

Distribution

The volume of distribution (Vss) sildenafil at steady state is an average of 105 liters, indicating that its tissue distribution. Sildenafil and its major circulating metabolite N-desmetilovy by approximately 96% binds to plasma proteins. Protein binding does not depend on the total concentration of the drug.

In healthy volunteers who received Viagra (100 mg once), less than 0.0002% (average 188 ng) dose was found in semen after 90 minutes after administration.

Metabolism

Sildenafil is primarily metabolized by the action of CYP3A4 (major route) and CYP2C9 (optional pathname) of the liver microsomal isozyme. The main circulating metabolite formed by the N-desmetilirovaniya sildenafil. According to the selectivity of action comparable to sildenafilom FDE metabolite and its activity against FDE5 is approximately 50% activity of the drug. Concentrations of metabolites in plasma is about 40% of the sildenafil. N-desmetilmetabolit continue under its metabolism, during his terminal half is approximately 4 h.

Derivation

Total body clearance of sildenafil equal to 41 l / h, terminal elimination half - 3-5 h. After ingestion or intravenous sildenafil is in the form of metabolites mainly in the faeces (approximately 80% tax-dose) and to a lesser extent in the urine (approximately 13% imposed dose).

Pharmacokinetics in special patient groups:

Older people

In healthy elderly volunteers (65 years and over) reduced sildenafil clearance and the concentration of free drug in plasma by approximately 40% higher than in young healthy volunteers (18-45 years). However, an analysis of safety data showed that age does not influence the frequency of undesirable events.

Renal

In volunteers with mild (creatinine clearance 50-80 ml / min) and moderate (creatinine clearance 30-49 ml / min) the pharmacokinetics of renal Viagra after a single oral (50 mg) did not change. In volunteers with severe (creatinine clearance <30>

4. Clinical part.

4.1. Indications for Use

Viagra is used to treat erectile dysfunction.

Contraindications

Viagra is contraindicated in patients with hypersensitivity to any component of the tablets.

Thanks to the well-known effects on the exchange of nitric oxide / tsGMF (see Pharmacodynamic properties). Viagra amplified hypotensive effect of nitrates, so its use contraindicated in patients receiving nitric oxide donors or nitrates in any form.

4.3 Dosage and Administration

Viagra tablets are inside.

The use of adult

Recommended dose is 50 mg taken, if necessary, about an hour before anticipated sexual activity. Given the efficiency and portability of the dose may be increased to 100 mg or decreased to 25 mg. The maximum recommended dose is 100 mg. The maximum recommended frequency of application - once a day.

* Request for elderly and patients with renal or hepatic

The elderly and patients with renal or hepatic impairment is recommended applying the same scheme.

The use in children

Viagra should not be for children.

4.4. Special warnings and precautions

To diagnose erectile dysfunction, to determine possible causes of their choice and adequate treatment is necessary to compile a complete medical history and perform a thorough physical exam.

Sexual activity poses a risk in the presence of heart disease. In this respect, before any therapy in the erection of violations doctor considers it necessary to study the cardiovascular system.

Drugs used to treat erectile dysfunction, you should use with caution in patients with anatomical deformation of the penis (eg angulyatsiya, cavernosal fibrosis or Peyronie’s disease) and those suffering from diseases that predispose to the development priapizma (such as anemia cell anemia, multiple myeloma or leukemia).

Drugs used to treat erectile dysfunction should not designate the men for whom sexual activity is undesirable.

The safety and effectiveness of Viagra in combination with other funds intended for the treatment of erectile dysfunction, has not been studied. In this sense, the use of such combinations is not recommended.

Viagra does not affect bleeding time, even in the appointment, in combination with aspirin. In vitro studies of human platelets indicate that sildenafil increases antiagregatsionny effect of sodium nitroprusside (nitric oxide donor). Information about the safety of Viagra in patients with diseases accompanying bleeding, ulcer or exacerbation of the disease is not. In this sense, these patients must use Viagra with caution.

A small number of patients with hereditary pigmentary retinitom there are violations of hereditary retinal fosfodiesteraz activity. Information about the safety of Viagra in patients with pigment retinitom no. In this sense, these patients must use Viagra with caution.

4.5. Interaction with other medicaments and other forms of interaction

Effect of other drugs on Viagra

In vitro studies:

Sildenafil metabolism is principally under the influence of the isoforms 3A4 (major route) and 2S9 (less meaningfully), cytochrome P450. Therefore, inhibitors of this isoenzyme may decrease the clearance of sildenafil.

In vivo studies:

Tsimetidin (800 mg), a non-inhibitor of CYP3A4, while admission to the Viagra Sildenafil causes increased plasma concentrations by 56% in healthy volunteers.

Population pharmacokinetic analysis of clinical studies showed a reduction in sildenafil clearance while the application of inhibitors of CYP3A4 (such as ketokonazol, erythromycin, tsimetidin). However, the frequency of undesirable phenomena in these patients is not increased.

Only receive an antacid (magnesium hydroxide / aluminum hydroxide) did not influence the bioavailability of Viagra.

According to a population pharmacokinetic analysis of the CYP2C9 inhibitors (such as tolbutamide, warfarin), CYP2D6 (such as selective serotonin inhibitors reverse the seizure, tricyclic antidepressants) and tiazidopodobnye thiazide diuretics, loop diuretics and kaliysberegayuschie, inhibitors of APF , calcium antagonists, beta-and adrenoblokatory inducers of CYP450 metabolism (such as rifampicin, barbiturates) have no influence on the pharmacokinetics of sildenafil.

Viagra’s effects on other drugs

In vitro studies:

Sildenafil is a weak inhibitor of cytochrome P450 isoenzyme - 1A2, 2S9, 2S19, 2D6, 2E1 and 3A4 (IK50> 150 mol). Andalusia sildenafil implement the recommended dose of its maximum concentration in plasma is about 1 mol, therefore, unlikely that Viagra can affect the clearance of isoenzyme substrates.

In vivo studies:

Signs of significant interaction with tolbutamidom (250 mg) or warfarin (40 mg), metabolized by CYP2C9, is not revealed.

Viagra (50 mg) did not produce an additional increase in bleeding time to receive aspirin (150 mg).

Viagra (50 mg) was amplified hypotensive effect of alcohol in healthy volunteers at the maximum level of alcohol in the blood of an average of 80 mg / dL.

In patients with signs of hypertension interaction Viagra (100 mg) with amlodipinom not detected. The average reduction in blood pressure in the prone position (systolic - 8 mm Hg. Art, Diastolic - a 7 mm Hg. Art) was comparable to that on receipt of a Viagra in healthy volunteers (see Pharmacodynamic properties).

Analysis of information security has demonstrated the lack of differences in the nature of side effects in patients taking Viagra in combination with antihypertensives in without them.

Viagra amplified hypotensive effect of nitrates in the sample of acute and long-term use in the past. In this sense, the use of Viagra in combination with nitrates or nitric oxide donors contraindicated (see Contraindications).

4.6. Application of pregnancy and lactation

Viagra is not designed for use in women.

In reproductive studies in rats and rabbits sildenafil oral application is not teratogenic action does not affect the reproductive function and does not cause a violation of peri / postnatal development of the fetus and newborn.

Unique in receiving a dose of Viagra 100 mg in healthy volunteers has not been accompanied by changes in sperm motility or morphology.

4.7. Impact on ability to drive and use machines

When driving, or require special precautions.

4.8. Adverse Reactions

In clinical studies conducted in several countries around the world have used Viagra, more than 3700 patients (aged 19 to 87 years). Over 550 patients were treated for more than a year.

Portability Viagra was good. Platsebokontroliruemyh In clinical studies the frequency of discontinuation of treatment due to unwanted effects was low and comparable to that when receiving placebo. Unwanted effects were generally transient and light or moderately expressed.

In studies with all models of undesirable phenomena in patients who received Viagra, was similar. In fixed dose studies of the frequency of undesirable events increased with increasing dose. In studies with the selection of doses chosen (such as research to better reflect the implementation of the recommended regimen), the nature of unwanted effects was comparable to that in studies with fixed doses.

In clinical studies, with a selection of individual doses, the majority of the following reactions phenomenon, linking the dose reduction was possible, probable or unknown:

Cardiovascular: headache, flushing, dizziness.

Digestion: dyspepsia.

Breathing: Nose mortgaged.

Senses a change in vision (light and transient, especially changing the color of objects, as well as an increased perception of light and clarity of the violation).

If you are using the drug in doses that exceed recommended, adverse reactions were similar to those mentioned above, but usually meet more often.

Priapizma cases not marked.

4.9. Overdosage

In studies in healthy volunteers who received the drug in single doses of 800 mg of adverse events were comparable with those of Viagra intake in lower doses, but have met more often.

In cases of overdose should take the standard symptoms. Dialysis should not accelerate the payment sildenafil, as the last activity is associated with plasma proteins and does not appear in the urine.

5. Part of the pharmaceutical industry

5.1. Composition

Viagra 25 mg tablets: blister packs of aklar / aluminum containers of 1,2, 4, 8 and 12 tablets. Bottles of high density polyethylene and 4, 8 and 12 tablets.

Viagra 50 mg tablets: blister packs of aklar / aluminum containers of 1, 2, 4, 8 and 12 tablets. Bottles of high density polyethylene and 4, 8 and 12 tablets.

Viagra pills 100 mg: aklar ampoules / aluminum containers of 1, 2, 4, 8 and 12 tablets. Bottles of high density polyethylene and 4, 8 and 12 tablets.

Important news

All you need to know about generics before deciding on a purchase.
If you think you know what Viagra - no hurry. Read this text to the end, and you can learn a lot about the pharmaceutical companies, government, and his doctor, and they are hiding from you!
Dear friend!

Five years ago, I thought that my life is over. I was a complete cipher. I was in very serious condition. I felt like all tuzhe rope tied around my neck …
I thought you could never get used to not be able to learn to live with it …
Nobody in the whole universe can not help until I realized their own problem!

I realized that there is nothing shameful in that, I have some problems with achieving and maintaining a full erection. This is a fairly common medical problem, just like arthritis, kidney stones, or, for example, diabetes.

My life changed dramatically the perception of the ease of dealing with this problem!

The second thing I discovered for myself - must not dither in this state - because you are not the only one who is able!
National Institute of Health (USA) has estimated that worldwide 30 million men have a similar problem.

Doctors call it "erectile dysfunction". And unfortunately, people who suffer from erectile dysfunction, there are plenty of reasons for the disorder:

Firstly, everyone knows that, on average, every man thinks about sex 8 times a minute. So, willy-harm than good problem constantly reminds you - if you’re a sex or not.

Secondly, in a world of little things that can compare with the night they spend together on a bed …
And thirdly: the sex is addictive!

In fact, sex is very similar to the drug - which crashed due to relations rushilis careers, the Empire came to nothing.

And on top - not the substance, it is important to say or think, no matter what circumstances you are - you will always remember about sex … about the quality … the number, how you been good (or bad) …

No?

Therefore, - all these thoughts and images in your head, the endless memories of sex - all this, when you suffer from erectile dysfunction, which leads to despair!
Life becomes empty!

After all, what I wrote, tell me: is there light at least one person who does not want sex you like me?

Listen. Listen carefully.
Having a healthy sex and enjoy sex - that is their inalienable right to every person from birth!

Each person who suffers, erection problems, there are at least three ways:

- Cease to be a complete man, and as a result - the loss of self-esteem and moral level,

- Continue for shame and humiliation because of a weak erection and upset because of an inability to meet a partner (by the way: the majority of women with the understanding that apply to this situation, but no patience is unlimited, and attention can result in dissatisfaction and frustration)

- Switch to other activities: fun not to have sex, but because of work or a hobby (this is also the option, but since then, and wish that this happiness?)

But the results of the three modes of life will be one: the gradual deterioration of the quality of life in all respects, although not directly related to sex.

Let us stop for a minute. Think about your sex life now. You are completely satisfied with it? And most importantly - who is very happy with my partner? Are you sure that all their partners orgasm - Really? Or there is no such certainty? Maybe your girlfriend simulated orgasm that just does not disturb you?

For reference: according to statistics, about 80% of women at least once in their life to simulate orgasm.
If any of my questions apply to you - you know - this is not your fault!

As I have said about 30 million men in varying degrees, suffer from disorders of the power. And if to be precise - the 52% of men aged 40 and 70 have some form of sexual disorders in the area.

This package should continue to add hundreds of bad advice and opinions that come home without the "experts" who often "everybody knows", but actually very little awareness (god knows where all this knowledge …)

Fact: 91.3% of all cases of erectile dysfunction due to side effects of other physiological disorders:

- High blood pressure

- High cholesterol

- Diabetes

- Operation (some surgical procedures can damage arteries and nerves around the genital organs)

- Heart disease

- A side effect of some drugs

- Hormonal Imbalance

- Psychological (stress, depression)

and other causes.

There are various reasons from time to time, some - life.
YOU ARE IN TIME satisfied with his erection?

If not - it’s great that you’re reading this text, because what I say, may be more important that you do hear in your life.

Okay, you do not hear every day that could change everything and restore to a full life?

I do not know at what point is your erectile dysfunction. I do not know what brings you pain.
But I know that most - if your sex life has ceased to meet with you, you have to do until it was too late!

You do not want to be a sad guy who walks with his head down and loss of sight? That are very bad with sexuality? And at worst - only not? And constantly remind the glorious youth, when everything was fine?
Good news! Since then, there is no more reason not to have a good and healthy sex!

The thing here is:

In March 1998 the Committee on Drugs (FDA) approved the application of a drug called "Viagra", designed for men suffering from erection disorders.

There is no doubt that you ever heard the word "Viagra."

Viagra has been called the "drug of the new millennium." Important role in this has been that it has helped 23 million men worldwide.

Why? The answer is simple:

Viagra - is the first product in the world, whose success in the treatment of erectile dysfunction is clinically proven.
More than 13,000 clinical trials were conducted before Viagra was launched in the market.

If you are experiencing difficulties in achieving or maintaining an erection, Viagra will more accurately the love of your life … without any anxiety about the duration and strength of his erection.

Listen, you deserve the "slaughter" of sex and full sex life. Not just different, namely the "slaughter" of sex - regardless of their years … Preparation … or physical capacity.

For example. Close your eyes for a moment and remember how good it was when you were a teenager, and could deal with this all night …

Well, Viagra gives you the chance to feel the "channel" of the new sex!

Let me explain what happens to your body and how …
Viagra can literally save your life and build relationships!

If you suffer from erectile dysfunction, which means that blood flow to your penis in the difficult moments of intimacy. When it began, the body increases blood flow to the penis. His penis is growing, and this allows you to be strong and excited.

Viagra "unlock" all the arteries or vessels in his penis, cork, making it difficult and filled with blood to achieve a full erection.
The best that can be said about Viagra … it works when you’re 33 years when your 73 years!
And that actually works and returns a complete assembly, even if the problem was 5 years … or even 25!

Viagra 100% guarantee of a significant improvement in their sex lives.
With Viagra, it will never be disappointed by sex, ever!

Several meritorious Viagra:

- Improve your sexual strength and power - which will again feel the excitement and enthusiasm of turmoil, once again, before they started with erection problems!

- To restore a vigorous and healthy sex life between you and your partner and restore their relationship (at least - to improve seriously)

Think about how difficult it would be if all this is happening with your partner, not you and your partner would be in their place? I have news for you - despite the patience of women more than men, in the end, have exactly the same sexual needs.

When your penis should be as full of blood, the skin becomes thinner and stronger than strong, which means more powerful orgasm, and not only you but also your partner!

- Renewed interest in sex, even if you have not experienced. And this, as we have found a radically better quality of life and other areas.

- Will allow you to once again feel what you feel for the first time, repeating the proof of the passion that once more before you feel so good to have sex with my partner again and again.

- You once again start to enjoy before caress with a partner rather than ashamed of his painful and unnatural in the moments before the sex.

- Raise your self esteem! When you undress - a woman who wants to see a man, who in turn will give you confidence.

- Your penis will remain strong for the whole sexual act. (You can trust him, how to trust a Swiss bank.)

- Do Viagra in a very high security. This is confirmed by 9 years of use of Viagra and the fact that 23 million men who had. This is more than the total number of people (men and women), Finland, Iceland, Jamaica and New Zealand together. And the proportion of side effects has increased in recent years.

- Viagra is very easy to use. Just take one pill 30-60 minutes before sex. Viagra works for 4 hours. Do not be afraid of anything - everything is under control. Viagra takes effect only if you are in a state of sexual arousal. The fact that Viagra works 4 hours, does not mean you will have an erection for 4 hours continuously. This means that it will only be able to get an erection in any event, the excitement during these 4 hours. For example: when you touch or kiss your partner, often start to breathe, and skin "running creep" - that means sexual excitement - just a case of Viagra work. This means you can relax and act without haste! Everything that happens during sex occur in a normal speed, and (surprise!) Even longer than normal!

- Viagra may also help young people cope with the natural uncertainty and anxiety (put your hand on heart - those who have not suffered in his youth?)

- You can take Viagra on an empty stomach and after lunch.

- You can take Viagra along with most other medications. True, there are some medications for admission should be avoided receipt of Viagra, but will be discussed later.

- If you have heart disease, Viagra is not more dangerous for you than for healthy people.
Not bad for a small pill, right?

What if you’re constantly taking Viagra?

Most doctors have observed that his patients not only improves sexual function and relationships with partners - again, because they both start having sexual interest in them, which can only positively affect the relationship. And of course, almost immediately begin to feel better.

Usually, when people are happy in a pair, especially in the sexual sense, it can be seen to smile on their faces, hear their voices and see it with ease and confidence to walk. All this suggests that the couple is in complete harmony, and live with others.

And why Viagra is so popular?
The answer is simple: what really works!

Believe me, it is not a drug like Viagra not seized and no drugs are not always used the Viagra.

Furthermore, there is no medication and are close to the number of Viagra prescriptions - more than 600 000 doctors issued more than 22 million prescriptions for Viagra.
All this suggests that Viagra will be with us for a long time!

And as I said before, there is nothing shameful in that you are having problems with erection.

But they really should be ashamed to call …
This is what large pharmaceutical company deceives you, "VPARIVAYA" Viagra YOU THE PRICE OF 314% OF ITS PRICE OVER REAL!

Pharmaceutical companies are really super, and only laugh when the most money for their drugs.
And most importantly - the big corporations are in collusion with the government to avoid changing the situation is not in your favor!

And this is why: In recent years in the United States operates a health insurance program Medikeyr literally requires retirees to buy drugs for poor quality, not to exceed the limit of insurance.

Meanwhile, large companies as fat cat smiled, smiling from ear to ear. As you can see who has spared no time and money for their plan worked.

Dr. Ron Pollet, a Republican from Texas, said:

"The new program Medikeyr only enriches pharmaceutical companies at the expense of taxpayers and the millions of seniors, and does nothing to address the real problems of the cost of drugs … The big companies that are funded as Medikeyr through this program at the expense of taxpayers … the pharmaceutical companies want a huge benefit "
Yes, Viagra is a great thing for millions of men worldwide, but that does not mean you should give the last shirt to buy it.

You need not be pyadey seven in front and see what happens. Large pharmaceutical companies cheat and profit for you!

Think: Viagra, there are 9 years old. Can you remember any other product in history, which for a short time has become so popular?

Only 9 years old brand "Viagra" has become widely known around the world (used in 90 countries) increased in line with major brands such as Coca-Cola, McDonald’s and IBM.

A lot of celebrities seen in the use of Viagra:

- The legendary actor Richard Harris;

- Comedian Jim Curry;

- A real man and the actor Bruce Willis;

- World-renowned opera singer Luciano Pavarotti (who claims that Viagra has allowed him to be happy with his fiancée, who is 34 years younger than him!)

- 72 years old, father-founder of "soul" James Brown;

- The leading television Jerry Springer (Springer argues that provides an incredible sexual energy Viagra);

- And many others, wish to remain anonymous.

Well, despite the government and big pharmaceutical companies to shake up our wallets …
A wonderful new opportunity to buy Viagra at crazy low prices now available!

(at that time, while our government mad and powerful pharmaceutical companies and not prikroyut vein of gold)

So why is a new wonder, we wonder? Well, the first order …
You do not need a prescription to buy

Besides this, you need not only more!
In fact, you pay 63% less for Viagra.
Viagra and it’s called "Martha".

I will say that "Mark", but first:

though it is a little tedious, you should understand how to build their big pharmaceutical companies, and why is there so much money to pay for their medicines.

Once the other day I read in The New York Times alleged that Americans buy cheap drugs. Will actually buy the drugs at higher prices in the world!

But I only hope that very well known.

Currently, many of the governors, including Illinois, Minnesota, Iowa, as well as the mayors of New York and Miami to buy drugs outside the U.S., in countries where they are much cheaper!

Not deceive ourselves, because we have this not happen, at least in the near future …
Pharmaceuticals is the only product that is banned from entering!
Here’s how the big pharmaceutical companies powerful!

Think about it: if you buy something, somewhere is released here in America or from somewhere else, right?

There are only 2 options: either you have a national product, or import as well?

For example, drive a Japanese car, the French eat cheese and drink wine, beer, and European manufacturers. Bring the popular Italian designer clothes, buying clothes and accessories, produced in factories in China (including your IP od made in China), fuel tank of gasoline in the Middle East.

ut if you want to use 100% of authorized medicines to prolong life or improve its quality, without the risk of obobrannym the thread …
Good luck! Try to find!

Listen: I do not pretend to know how
How can I buy Viagra is cheaper than taking the video output?

And here’s how:

A very enterprising "Generic-Pharmacy Pty Ltd has invented a curious and intelligent solution for you:
Buy Viagra now 68.3% cheaper than that bought before!

But wait, that’s not all:

Specialists "Generic-Pharmacy Pty Ltd" went a step further - it also comes as a (legally of course) that sell for Viagra:
You do not even need a prescription to buy it.

As you can see - "Generic-Pharmacy Pty Ltd - a supplier of generic products. The company has offices worldwide, including USA, London, Tokyo, Japan, Beijing, China!

It turns out that many countries do not recognize the American restrictions.

India, for example, does not recognize. This means that Indian companies can manufacture and sell copies of drugs developed in the United States. I mean, absolutely identical copy, including
Viagra!

This is what these companies produce and is, as I said, generic Viagra. So what’s the difference between generic drugs ( "generic" Viagra) and the product brand (Viagra)?

The Federal Trade Commission is responsible for this issue is very simple. They say that the distinction is …
Yes innocent! Just no! Actually!

Of course, not counting the cost.
While Viagra is sold in your nearest drugstore at a price of $ 12 per pill, "Generic-Pharmacy SA sells generic pill only 21 cents and $ 2.

Another difference is that brand name drugs are called, as well as brand and generic name comes from its chemical name.

For example, Viagra - is sildenafil citrate, but it is much easier to pronounce Viagra generic.

So what is the generic Viagra:
This is absolutely 100% brand products IDENTICAL Viagra!

In fact, there is a harsh medical supervision and quality control that goes all the products of the company Ranbaxy (an Indian company that produces generic Viagra).

These standards were set by international regulatory associations such as the World Health Organization and the Food and Drug Administration in the industry, which is the control of compliance.

These organizations are also prescribe generic influence on the body as brand Viagra. In fact, the only difference Viagra Generic Viagra - the color of the pads! That’s it!

Generic Viagra contain the same elements in the same proportions as in the Viagra brand, with the exception of the mark!
Viagra stoitna 314% more expensive, but your penis eregirovan As with the generic Viagra with the brand!

Literally, the distinction for you:
That extra $ 9, and 33 cents left in your pocket every time you buy a pill for "Generic-Pharmacy Pty Ltd"!

Think about when you buy in the supermarket, frozen vegetables, sliced carrots and cranberry sauce brand, or the same thing, only under the brand of the supermarket? It is true that you save 50%.

Although, to be very precise - the same as broccoli, carrots, and the same sauce. … Thank goodness!
Since generics are exactly the same thing happening!

"Generic-Pharmacy Pty Ltd" now sells more than 217,000 tablets of Viagra, and India, where it launched production of the company has chosen not casually.

First, India has long been known, its medical school, who are not specialists. In fact it is fair to say that there is no hospital in America, that would not work, at least, an Indian expert.

Secondly, 80% of generics produced in India, including medicines that the doctor what is written.

Ranbaxy in India are cited as one of the most powerful and firmly standing on the feet of production companies. And not just in India, everyone!

As the largest in India, the company has achieved a lot and at the global level. Here are some indicators of their experiences:

formed in 1961 (Bill Gates was still in kindergarten)

- The company has production sites in 7 countries including China, USA and India.

- The company employs 8000 employees worldwide.

- In the year 2002 that have received government approval for the deployment of 455 new products in 74 countries.

You have probably already realized how profitable to produce and sell generic drugs on the market!

Okay, now let’s see how much you can save. There are different plans for you to order, here are 3 most popular:
Generic Viagra
Generic Viagra 100 mg
Price for the number of tablets. asset
Table 12. 135 p. 1620 rub. BUY
Table 24. 115 p. 2760 rub. BUY
Table 48. 90 p. 4320 rub. BUY
100 tablets. 75 p. 7500 rub. BUY

Uses normal male 10-12 tablets per month (depending on how many times he is the sex), and when you feel lonely, you’ll see:
How many money-saving generic Viagra. It’s amazing!

Let’s say you have 100 tablets per year (about 8 per month). If for them, which will cost 7500r. But if you buy Viagra at the pharmacy on the corner of 236r. Was 23,600. Feel the difference!
16100r. remain lying there - in your pocket!
As I said, saving 68.3% in each pill!

In fact, you can not have the opportunity to save that amount of money on something you buy!

Imagine, if you’re a family in a luxurious dinner in the restaurant and instead of paying 5,000 rubles, you pay only 1589 rubles! Understand? That’s what nearly 70% savings for you.

And because they buy generic Viagra through distributors outside the U.S. —
doctor if you do not need!
Generic Viagra is very easy to order. See how it works:

1. Visit the website for the sale of generics. You see a lot of options orders. Select the number you want (personally, I recommend 100 tablets). Well, if you first try the generic Viagra and only want to check, I think the 4 pills of purchase will be much easier.

2. You will have to answer simple questions about yourself and your health. Your responses will be reviewed by a licensed physician. It is important to answer truthfully the questions that the specialist can make a correct image about your health before advising the use of generic Viagra.

First, the physician must ensure that your heart is healthy to participate in an active sexual activity!

And a second! Although Viagra can be used in conjunction with almost all medications, there are still a number of drugs that are prohibited from using Viagra!

For example, you should never use Viagra if you take nitrates, even if the product contains only nitrate, anyway - never!

There are a few products with which you can not use Viagra, be sure to check with your doctor. I think you do not have time to explain that all questions are answered that the truth!

3. Then the doctor checks your answer and if he needed to talk to you if you send an email.

4. Once your request is approved by a doctor - who will send it to the "Generic-Pharmacy Pty Ltd", which was immediately implemented.

5. When your order is ready to send through the credit card to pay for it. In order to receive the next business day.
And not least, you generic Viagra in the usual cardboard box with labels and logos!

So you can get generic, such as home or office. Not understand anyone.

Sometimes you think that by taking a wonderful pill, which is immediately in the twinkling of an eye supergeroem sexual. Sometimes those thoughts lead to an opposite effect. And his "performance" falls.

Do not worry. This is normal! Just let the express generic Viagra! Sometimes, at least you have to wait 6-8 sexual contact, using one tablet of Viagra before each one until your anxiety will not go and not go to normal state.
And when it finally happens, remember - the prime of their sexual life with new colors and you will be able to experience these feelings, which had no time!

That’s what I’m saying - this is an extreme case, in fact, 94.9% of men who use Viagra generic noticed the effect after 1-2 times of use.

In fact, Viagra works much better than you can imagine. The first time you see it, you think this is just a coincidence.

Furthermore, "Generic-Pharmacy Pty Ltd" did not publish the personal information you have provided.

Imagine, from the appearance in 1998, Viagra has helped
23000000 men worldwide!

Regarding statistics, the results are truly amazing: every second worldwide sales Viagra pills 9! And over time, which led him to read this article
10,800 tablets of purchase on the same man as you.
Naturally, because this is a good reason!
Generic Viagra makes your life much better … allows you to relax … and feels much better … in general, enjoy life!

I can not even describe what a truly great changes occur in your life when you can have sex when, where and with whomever you want! And I’m not talking about changing attitudes toward sex, just say that in order to regain what they once were (as in my case, it is obvious).

You know what I am talking about. Viagra gives you:
guaranteed the opportunity to enjoy a deep sense of intimacy with your partner

way to clean PLEASURE!

Inflames passions and breathe fire in the relationship! Frankly speaking, not so long ago when you had sex, the Viagra again briefly in the long extinguished fires of passion!

Generic Viagra gives you the fun, the number of years than ever!
You can get all the benefits of Viagra to a much lower price than that offered by the giant corporations - the use of generics!
Generic Viagra and other popular medications for treating erectile dysfunction
- This is the happiness and all the prices!